Transcript:

Extinguish Inflammation at the Source

https://dreliaz.org/2020/03/attack-inflammation-from-home/

00:00:01
Andrew Whitfield
I’m Andrew Whitfield. Joining us on the line today is dr. Isaac Elias. Who’s an integrative medical doctor, licensed acupuncturist researcher, product formulator, and frequent guest lecture. He’s been a pioneer in holistic medicine since the early 1980s and has published numerous peer-reviewed research papers on several of his key integrative health formulas. He’s the founder and medical director of TBA medical clinic in Santa Rosa, California, and integrative health center, specializing in cancer and chronic conditions. Dr. Elias is also widely regarded as the leading expert in the field of modified citrus pectin research. 

00:01:39
Andrew Whitfield
And we warmly welcome dr. Isaac Elias to ethics medicine today. How are you, Isaac? 

00:01:45
Dr. Isaac Eliaz
I’m wonderful Andrew, and thank you for the opportunity to participate in this service that you are providing. I’m really excited and I’m excited to talk to people in Australia because I love a few times I have family in Australia and I just need a good reason to come back. 

Modified Citrus Pectin has been used Clinically for Years

00:02:03
Andrew Whitfield
We will hopefully give you that reason. I say, well, look, Isaac, firstly, we have to go back to modified citrus pectin. Now, this is something that I’ve used clinically for years and years with great effect in especially cancer patients. We’re going to be delving into a few other areas, but I’d really like to go back to where this all started with modifying a pectin, a citrus pectin. Where did the research start? Where does the idea start?

The History of Modified Citrus Pectin

00:02:32
Dr. Isaac Eliaz
It’s really, it’s a remarkable story that has a multifaceted, the person that originally came with the idea of modifying pectin to a low molecular weight, more for in vitro testing, for animal testing was a doctor Avraham Raz, from Wayne university with Israeli in his origin. This has been around many years is one of the people who discovered lectins and galectin in the late 80s. I just published actually a landmark paper with him on the function of modified citrus pectin in a high impact peer-review journal. We collaborate actually, and from a practical point of view, I’m a native of Israel. In 1971, I was 12 years old. You can calculate, I just turned 16. I was taking a walk in our neighborhood, our neighbors, Ruth and Leo Coin, both were PhDs in organic chemistry and were pioneers of the citrus industry in Israel. 

Modified Citrus Pectin in Isreal

00:03:38
Dr Isaac Eliaz
Israel was famous for its citrus industry. People may not be aware of most of Israel used to be citrus, plants, and trees, the main thing. There was a key organic chemist who developed the industry and out of the blue turned to me and I was 12 years old. He told me, Isaac, one day they will find a treatment for cancer from the peal of the citrus fruit. 1995, the first paper comes out and somehow it stuck in my mind, 24 years later, I pick up the phone, I call Ruth. I tell Ruth “Its Isaac”, very happy to talk. I don’t expect you to remember, but you told me this thing when I was 12 years old, I need your help. She put me together with the main pectin scientist in the world. We developed this very unique, modified citrus pectin called Pectasol. 

Scientific Studies are on one Specific Type of Modified Citrus Pectin

00:04:31
Dr. Isaac Eliaz
It’s important to emphasize because all the published papers and on the commercially available products are just on Pectasol, and of course, there’s always borrowed science with people who try to copy you and they use the generic name because modified citrus pectin is a misleading name. Every pectin needs to be modified to be taken out of the peal, right? You have to extract it, but its really Pectasol, which is the one that has the low molecular weight, this specific structure we have proven the only pectin to ever be shown where we have, we developed an antibody. We have shown absorption through the gut in human subjects. We know we are proven, it gets absorbed. Because of its unique structure, which we can reproduce, it has this really remarkable benefits. Otherwise, you mentioned, we all started by using it with cancer, but over the years we realized that its role in blocking galectin three is so much bigger than cancer. 

00:05:35
Dr Isaac Eliaz
That it’s literally mindblowing. 

00:05:38
Speaker 2
I do want to just put in a point for our listeners and that is that FX medicine tries to be a non-branded wherever possible, but in the interests of both skillset and safety for our practitioners around the world, I think it’s important to make this distinction that this is the research product. There is some when you cannot escape the naming of a certain product. So I just wanted to clarify that point. 

Lung, Liver, and Heart Benefits of Modified Citrus Pectin

00:06:03
Dr Isaac Eliaz
I really appreciate your comments. I always actually likely I avoid mentioning it, but we adjusted three, four landmark papers and there are over 20 papers showing without question the benefit inflammatory fibrotic diseases of lung, liver, heart, etc. And there was one paper published. They tell them they didn’t work and sure enough, it wasn’t, our product three takes one drop of lemon to spoil a bucket of milk, and people need to know this. This is why I decided once this happened and I did respond to the journal and they published my response and the original authors acknowledged the issue. I decided you know what? The world needs to know. I can’t be the best kept secret in town. That’s why I mentioned it now. 

What is Galectin-3?

00:06:54
Speaker 2
I want to go into why that’s important, but I think we need to backtrack first and talk about galectin three and that’s this receptor that’s involved in more than what I originally thought was. That was certainly like prostate cancer and maybe a few other cancers, like breast cancer. Can we talk about galectin three? What is this receptor? 

00:07:17
Dr Isaac Eliaz
Yeah, we can talk it’s more than so it’s very fascinating. If I can take two minutes to explain it. It’s interesting for me on a personal level, because you discovered you described the different areas of the type and expertise in, regular medicine licensed like you punctuate classical homeopathy, serious researcher, from the double-blind clinical trials with Harvard to task, to Columbia, to Johns Hopkins, I’m kind of going down to the East coast to the USDA, to MD Anderson, really dozens of institutes, but I’m also a healer. I’m mainly a healer. I’m mainly a hands-on practitioner. For me, I was fortunate to get trained by some of the most legendary Tibetan Buddhist masters in Tibet. I teach meditation and healing on a volunteer basis. It’s all about how to transform difficulties, negative emotions, survival responses into love, and compassion. Why am I telling this story? Because this is where I come from meditation into health, what I found out and it’s so fascinating. 

Galectin-s is Linked to Every Chronic Disease

00:08:23
Dr Isaac Eliaz
Our life brings you to what you need. Galectin-3 is our master survival, protein, and rich really important for the doctors to understand this. Our survival response is at the root of every chronic disease, because what is cancer? Cancer is one cell that decides to survive. What is an autoimmune disease that certain organ fights with the rest of the body? So this survival mechanism has effects, especially inside the cell. It helps to develop the cell normally because we want to survive, right? We are 50 trillion cells that are surviving together. We are a miracle each of them. Inside the cell, galectin three is important for embryogenesis for normal cell development. But this is not our issue. Our issue is on the cell membrane is the instead of the receptor and in the circulation. There, it allows different cells, different tissue, different bacteria, but to survive by creating a microenvironment. 

00:09:34
Dr Isaac Eliaz
Actually galectin-3 is defined as an alarming. It’s a protein that sounds the alarm. If 20 years ago we thought that galectin-3 is a chronic protein that is in charge of actually 20 years ago. We thought more about the cancer, but let’s say 15 years ago, 10 years ago, we realized it in charge of injury repair. He does it by creating inflammation and fibrosis, which is pretty bad. Now we know that galectin three in acute conditions like myocardial infarction, like sepsis. It goes up Andrew in minutes and it starts the whole cascade of inflammation. How does it do it? If we, if one looks at the structure of galectin-3, it is a carbohydrate recognition domain. So it binds to different carbohydrates. Oligosaccharides photoc lichens, the glycolipids, it binds to VGF. It binds to CA bind to sticky molecule like integrating it binds to fiboronectin. 

00:10:40
Dr. Isaac Eliaz
It binds to CD45 and based on what it binds based on the carbohydrate sugar signature, it will create different responses. It’s the muster protein that creates a microenvironment to allow the arterial sclerotic plaque to thrive. That allows an aggressive invader to create an impenetrable biofilm. It allows the cancer cell to create a microenvironment with hypoxia, et cetera. Galectin-3 goes up with H it goes up with any drama or stress or injury, physical, emotional, mental, psychological. We know we have studies about it. As a result, it degrades our body. Blocking galectin three, and this is not something I would say even five years ago, but blocking galectin-3 is in my opinion, the most important thing for longevity, because it affects literally if I showed you the child, every single chronic disease we’re right now doing research myself on multiple cancer, we’re starting a recent on scleroderma. 

00:11:57
Dr. Isaac Eliaz
We didn’t osteoarthritis. We starting on rheumatory arthritis. We are doing on idiopathic pulmonary fibrosis. We’re doing research on CKD, on AKI, on congestive heart failure and hypertension, all of these with the same compound. How is it possible? Because we are addressing our basic unhealthy survival instincts, which really causes havoc. It’s like the body goes to war with when it can survive with space. 

00:12:29
Speaker 2
Oh, okay. It’s not just a marker, but a target. For instance, you say that it goes up in minutes now. Normally we see things like, CRP, cytochrome C reactive protein, or ESR going up with it as an acute-phase protein to a stressor, but we don’t target that. We just measure it and we say, that’s how we measure what’s happening. We target other tissues. However, this turns out to be a target, not just a measure. 

00:13:02
Dr. Isaac Eliaz
Absolutely. We know that it’s a target because when we block it, the condition reverses itself, it’s not only stopped, but in certain condition, you look at any most studies with sclerosis, with Arterial sclerosis, with fibrosis of the heart, with kidney damage, with heart, with liver damage. You actually not only stop it in many studies, we actually reverse it because there is still energy in the tissue. 

00:13:33
Speaker 2
Yeah. Right. Okay. This is something I picked up when you said AKI, that’s acute kidney injury. If you don’t nip that in the bud really quick, you couldn’t possibly lead to devastating disorders like sepsis. If you, if we can recover this early enough, if we can be maybe measuring galectin-3 in the serum and address acute kidney injury in its early stages, we could be preventing the progression of sepsis. 

Galectin-3 Studies

00:14:04
Dr. Isaac Eliaz
Of course, this is, it’s so interesting that you are jumping. It’s kind of amazing because we had full papers of this lately. I just came back from China. When I lectured in a, to me, I mean, I’m like a holistic outpatient doctor. I actually lectured at an international critical care conference. Okay. I see you conference because of the galectin-3, because now there are studies showing, listen to this really good study, high impact journal that ate a combination of human study and animal study. In the human studies that showed that patients who survive sepsis in the ICU 1100 patients, their damage to the kidneys was proportional to the level of galectin-3 at the time of discharge, but more important patients who are going to give coronary artery bypass, okay. Their level of pre-surgery galectin-3 directly correlated to the kidney damage and the heart damage from the surgery, unreal. 

00:15:12
Dr. Isaac Eliaz
What they found out when they took enema, when they did an acute kidney injury, by shutting down the circulation to the animals, if they gave them the modified citrus pectin, they actually eliminated the damage to the heart, not only to the kidney, to the heart. Why is AKI so important? You can even take AKI and you have no longterm kidney damage. Guess what I mean, alarming has been set on in the bone marrow and the alarming is going to go to the target organs. Like the heart is going to cause the remodeling of the heart and the historic dysfunction and stiffening, fibrotic, heart, and early death. It all started with the kidney injury and the mediator exclusively for this was the main one is galectin-3. When you block it or where you do it in animals that don’t have galectin-3, you don’t get this damage unreal right. 

00:16:17
Speaker 2
Now. Also you mentioned, fibrosis, endothelial fibrosis and I’m picturing here things like fibrotic plaques. Fibrotic caps, can we, manipulate modulator an atheroma by the use of modified sheets? 

00:16:37
Dr. Isaac Eliaz
Absolutely. We know research has shown is even years ago, they’ve already shown that from all fibers, pictures out are most effective for placks in general. Of course, we know why, if you look at the fibroblasts and myofibroblasts, if you look at TGF beta as a driver of the fibrotic process, TGF beta is excreted from macrophage in response to galectin-3 cause inflammatory and I L one B I L thin I L H I L for TNF, alpha all are excreted from inflammatory macrophage in response to galectin-3 extracellular matrix, eh, modulation increasing in extracellular mesenchymal STEM cells, which causes fibrosis excreted stimulated by galectin-3. In the same time, the collections, we will go to our normal T-cells and we’ll shut down the normal immune response. If you take two cells and you put the galectin three, no cytokines, zip energy, complete why that tells a cancer survivor, you can say smiled. 

00:17:53
Dr. Isaac Eliaz
It also uses the galectin-3. It wants to survive. We talked about it. You put a galectin three blocker. Guess what? You get your cytokines back, you get an immune response with less inflammation. That’s why it’s a winning combination, less inflammation, and better immune response. 

00:18:13
Speaker 2
Yeah. I think he may have actually answered a question that’s dogged me for years. That is with regards to the macrophage, something initiates the macro files to turn into a foam cell. I’ve always wondered, does the macrophage turn into a foam cell upon engulfing oxidized LDL in the blood or after it migrates into the Tunica intima of the artery? I E does the inflammatory or atherogenic process start after that foam cell has migrated or does it initiate before? And I think what you’re telling me is that it’s initiated within the blood. 

00:18:57
Dr. Isaac Eliaz
Yeah. But it’s interesting. It’s a great question. Great observation. I just spoke about it. So the body communicates. For example, when you’re doing AKI. You do an AKI on an animal. Is a knockout mice. No galectin-3. You don’t get the response. Then you transplant into the bone marrow. Into the bone marrow. Yeah. You advanced bone marrow. That is normal bone marrow. From the AKI XE, macrophage in the bone marrow gets stimulated. They excrete galectin-3 is it goes into the house and then local macrophage also spike in response to the bone marrow. You have a systemic response and do you have an extracellular response? But if you cut the systemic response, you will affect the XSL response. We see it when we give modified citrus pectin with downregulation of expression of galectin-3 intracellularly, the cell knows that it’s safer. 

00:20:11
Dr. Isaac Eliaz
Now it doesn’t have to excrete so much galectin-3. It’s into a cage relationship, but you’re right. It starts falling away sometimes. So from the target tissue, totally. 

Modified Citrus Pectin could Save Healthcare Billions

00:20:22
Speaker 2
You think about health care dollars spent on heart disease and hospitalizations, indeed, real hospitalizations, chronic care, and all of that thing. This could save the healthcare dollar of countries, millions. This is a huge preventative, 

00:20:40
Dr. Isaac Eliaz
Billions billions actually, billions, not millions because, CKD chronic kidney disease is the biggest. Even with the overcharging in the field of cancer. CKD is the biggest expenditure of the medical system in the United States. A lot of this can be prevented. The sepsis patients, 600,000 in the United States, all the bypass patients that get the complications afterward and you can prevent it literally either by taking modified citrus pectin or mainly just by taking more differences, to speak to them, developing some more dramatic medical devices for the ICU. We’re going to filter out the galectin-3, but it’s many years out. We have shown now that just by giving modified citrus pectin, it was expecting, we actually modulating the effect. We are showing that, and we’re going to publish this soon, that in kidney damage models, if we just feed the animal, my modified citrus pectin a week before, and then we do the regular injury. 

00:21:46
Dr. Isaac Eliaz
Okay. We are dramatically changing the outcome, which is similar to the study about the levels of galectin-3 preoperatively. We will determine what will happen afterwards. Underweights based on what you said, it’s the cell in the blood is sending a signal to the target tissue. So we are cutting the signal. 

00:22:09
Speaker 2
I just want to make this clear in my mind. If you have a galectin-3 knockout mouse, and you induce forgive me, but this is how science is done. I hate this, how this happens to animals, but it’s the way. If there is an injury initiated in that mouse that has no galectin-3, then that acute kidney injury let’s say does not progress because it can’t drive it further. Is that, is that true? 

00:22:37
Dr. Isaac Eliaz
Right, right. Yeah. In this specific study, it did not create damage to the heart. They were interested in the kidney, too, exactly. In the knockout animal and in the regular animal when you gave MCP (modified citrus pectin). When they took the knockout animal and they just created a bone marrow, they take the Galectin-3. They were able to still create the damage because that’s why it’s such an elegant study that got so much attention. The signal to this specifically, the identify, the inflammatory macrophage, just like you were talking about. They are the ones who created the effect. Again, when you give galectin when you give our modified citrus pectin, when you take Pectasol, it canceled the negative effect. 

00:23:22
Speaker 2
Now I just want to talk about modified citrus pectin and the attributes that it must have. It’s gotta be of a certain size and it’s got to have low esterification. Correct. Can we talk, can we discuss why that’s important? What causes the problem? If there is high esterification, for instance, 

Why Modified Citrus Pectin needs Low Esterification to be Effective

00:23:42
Dr. Isaac Eliaz
It’s a, talking structure, it’s almost a bit of a mystery. The idea is a much greater affinity for binding to a two positively charged material like heavy metals. Eh, we have a number of very impressive papers on our ability to bind to led to mercury. We just published a paper on uranium, eh, binding an increased excretion in the gut in a peer-reviewed journal. It’s also, you have to preserve the side branches of the pectin. When, for example, very unique feature we have in Pectasol that it has 10% of rhamnogalacturonan-2 and around the block 202 is for example, the active immune-enhancing compound and mistletoe is electron and two. We went, so I aware of it until we did the study on volunteers and we tested different medicinal mushrooms because I love medicinal mushrooms to induce immune effects. We tested our MCP and we never published on the mushrooms because our MCP was so much more effective and it is time. 

00:24:59
Dr. Isaac Eliaz
It is almost, this is almost 15 years ago. We really didn’t completely understand even why. Now we know, because it allows the immune system to respond. So this specific modified citrus pectin. The other thing that we have found talking about modified citrus pectin, which actually it’s a mistake I’ve made. We see effects of modified citrus pectin it’s a partial dose. If the full dose is 15 grams a day, they can two or three times a day. Based, 15 minutes before food is enough and maybe an hour after food then because of the response I used to recommend for maintenance five grams a day. What I’ve found, especially in the last year is it, if you have any health issues, if you really take the full dose, you will see different effects. One of the effects that you see is a metabolic effect. Why is this? Because the insulin receptors, when you have metabolic syndrome, you often have extracellular inflammation. 

00:26:08
Dr Isaac Eliaz
You have inflammatory macrophage, but often the inflammatory macrophage creating galectin three that blocks the insulin receptors. As a result, a MPK gets blocked and then mTOR, Y and mTOR1 hypoxia and using factors get turned on. PDK gets turned on, PDH gets blocked. The mitochondria shuts down and you get abnormal metabolism. You see this in diabetes, you see it in metabolic diseases, you see it infection. Of course, you see it in cancer because of the microenvironment. There is something about people taking the full dose. I know from my own personal experience that I finally, I had the mobile been A1C, no matter what, five, eight, five, seven, five, eight. Now I just increased my, MCP dose to full dose. Sure enough, it’s down to 5.4. I haven’t been in 5.4 for 15 years. 

00:27:07
Speaker 2
We could use this, not just as an initial treatment to, purportedly block the initial insult, but we can actually use this to track response. That’s what I’m wondering here. We could use this. Let’s say that, the normal waxing and waning of autoimmune disease, for instance, we could use increasing and decreasing a dose along with the inflammation that accompanies rheumatoid arthritis or other, auto-immune diseases.  

00:27:39
Dr. Isaac Eliaz
You are really picking very interesting. Auto immune diseases, for example, my Twitter, right, is, all of them will have very high level of collecting three, but it’s important to talk about testing for galectin three, because it’s a double edged sword. ? Why Because we have a relationship between galectin three being in the blood stream as monomers and being as Pinta merits, which means five Galatians, three attached together. The antibodies, it detects the galectin three attaches to the intermingle, not to the Cabo. I go to recognition domain, and it can read the pentameter as one galectin three, right? So you cannot decide on treatment based on collecting three level. When people ask me who needs to get to take modifies it respecting, I tell them anyone that is breathing because of its very basic structure. However if you have a healthy patient, it is really doing well. 

00:28:41
Dr. Isaac Eliaz
Let’s say somebody in their mid thirties, they’re really doing well, no health problems they’re doing great. You happen to check the galectin three and it’s no it’s in the high teens, 17, 18, 20, they’re a ticking time bomb. It’s much higher than you expect. These people need to go in a full dose, modified it to spec them. You need to look for fibrotic places in the body that can produce galectin three in one area is scars on the surface, scars from surgeries scout, after infection, emotional scars, things that are producing ongoing inflammation and repair and addressing them is very important because galectin three is Gladius. We increases in level as we age and very interesting. We compare levels of galectin three in Centurion compared to people between 70 and 80. It’s a really nice study and we have to do it. We have to remember that the ones who are 70 and 80 include a few, which are going to become Centurion. 

00:29:57
Dr. Isaac Eliaz
The centurion’s Everett levels of galectin three are very significantly lower than those between the seventies and eighties, but you can see the seventies and eighties. I can send you the study. It’s really neat. You see the cluster of the Logan act in three, and these are probably the ones that are going to make it to be Santeria. 

00:30:17
Speaker 2
Right. There’s a point that you made earlier, also about the structure of the modified citrus pectin. And you mentioned a REM nose molecule. 

00:30:26
Dr. Isaac Eliaz
Yeah. The rum. No galactorrhea and then too. Right. 

00:30:29
Speaker 2
Gotcha. What I’m wondering about here is interaction at the gut level interaction with the glycocalyx or the mucus of the gut lining. I’m wondering about T-cell you were mentioning energy before, so T cell activation or modulation so that we can get, T zero rather than T one to T 17, et cetera. How effective is modified citrus pectin on treating at the gut level and how like, have you looked at absorption studies and all that stuff as well? 

00:31:07
Dr. Isaac Eliaz
Yeah. W w we know as though it’s good absorption and we know the T headlights, we haven’t published yet, but it’s between eight and 10 hours, but it’s interesting. We have between four and six different papers specifically on our modified it, respecting showing the benefit in enhancing, for example, antibiotic therapy in improvement, in reducing resistance to aggressive bacteria and in any. We definitely have a number of papers showing the importance of modifieds it respecting in balancing the microbiome and the biofilm, because the collection three is the key structure of the biofilm. A lot of the molecules that we try to target people say they are heavy metals. They are oxidized lipids. They’re all sitting on the galectin three. There are many papers on galectin three in relationship to the gut mucosa and to the, into the biofilm aggressive bacteria. If it’s staphylococcus salmonella, they use galectin three to anchor into the gut lining and create issues with that. 

00:32:24
Dr. Isaac Eliaz
We’ll we’ll increase the permeability in the gut, et cetera. From this sense, one thing that I see, for example, in Lyme patients that usually are sensitive to almost everything they will tell you when they take motivated suspecting. Wow. It really feels good. I really feel my gut. 

00:32:43
Speaker 2
Is, so is this acting on, lipopolysaccharide activation of mucosal infiltration, if you like, or activation at the gut lining level of an inflammatory process, 

00:32:58
Dr. Isaac Eliaz
This is a great comment lipopolysaccharide binds to galectin three. Now you start to get into the other piece of it, like in sepsis three. Okay. It’s going into the nasty places in the body, right. It’s the river it’s delivering your lipid poli saccharide where the saccharine is bound to the galectin three. You take modified it respecting and you competitively get rid of the lipopolysaccharide and you cut down the inflammatory process, different from sepsis don’t die from the infection. They died from the abnormal, if not inflammatory response. Absolutely. We know that LPs is directly related is carried by galectin three. Definitely what you said is extremely accurate. 

00:33:45
Speaker 2
Okay. That would then tie into what you were speaking earlier about with regards to liver fibrosis. Do you see gal three in the actual cook for cells of the liver? Do you see increased gal three in there? And I’m wondering here about the use of modified citrus pectin in things like nonalcoholic, fatty liver disease in, as you said, liver fibrosis in alcoholic liver disease in Hep C. ? Right. 

00:34:13
Dr Isaac Eliaz
I do. I feel like you’re reading my mind from Asia, where I specifically was looking at this. There is solid evidence on the role of galectin three Nash colleagues. That that’s what you mentioned, which, honestly many doctors and they don’t realize what a huge problem it is. Millions of people and the us, even just some dragon development specifically for Nash, you zap, there are papers on our modifieds with texting showing reversal of liver damage when you give them a decisive perspective. Absolutely Nash is driven by galectin three it’s galectin three that will determine all you’re going to go into fibrosis or not. Modified it to spectrum is very important for Nash patients, but again, you kind of expect it based on what we’ve been talking about. It drives inflammatory in the fibrotic. Absolutely Nash is a big target, 

00:35:15
Speaker 2
Two things I’m wondering about with combinations here. The first one is with regards to sepsis, it’s diagnosed late and it’s misdiagnosed often and, drug treatments that would, previously tried like one called Xigris was found not to work. There’s doctors now crying out for help. Indeed doctors who are normally totally dismissive of complementary approaches are now initiating intravenous vitamin C to help reduce sepsis. 

00:35:48
Dr. Isaac Eliaz
Lovely, amazing study because if this study that you’re referring to was a drug, every ICU that would be using vitamin Civ. 

00:35:56
Speaker 2
Yeah. You’d think you’d hope. 

00:35:59
Dr. Isaac Eliaz
So. It’s a great combination and why it’s a great combination because vitamin C modulates the extracellular matrix. In this sense, it picked us all will be very helpful. We have a very reputable, for example, physician from Southern California, who got sepsis, who got infection in his hand and did not respond to it. It turned into sepsis did not respond to antibiotic. This happened like three, four months ago. He was just scheduled for amputation of them literally within hours. Okay. And he knows me. He went on a full dose of motivated perspective, plus our mushroom combination that is very similar. I know legal saccharides and sure enough, it started responding and it went away. The ideal for this patient, it would have also done. High-dose either level of vitamin C. So yes, it’s a very good combination. As you said, I mean, people don’t realize there is very little interest in developing drugs for sepsis. 

00:37:06
Dr. Isaac Eliaz
Surprisingly. Now I have, I got an NIH grant from the NIH to study removal of galectin three and sepsis, because there is very little as an alternative guy. There is very little interest in big pharma because it, Tyler it’s hard to prove and nothing is working, in hundreds of thousands die every year, hundreds of thousands in United States, 600,000. 

00:37:31
Speaker 2
What about with regards to, we’ll talk about your research in one second, but I guess, firstly, I want to talk about the concurrent use of modified citrus pectin with chemotherapeutics in cancer, chemotherapeutics. We’re talking about here, are there any caveats that you have to be aware of? Like for instance, the biologics that are now out on the market, the monoclonal antibodies, do we have to be cautious with any of these? 

00:37:57
Dr. Isaac Eliaz
Another excellent question. We have now multiple studies in vitro in vivo some human data showing that MCP is synergistic practically with every chemotherapy. We specifically have data showing that MCP synergistic with PDL one inhibitor, we know as a mechanism. All these biological, Keytruda and nivolumab differently is one inhibitors. We specifically understand why, because when you modify the intracellular metabolism, when you block in PK, because of the receptors you are increasing PDL one expression. So actually it’s very important. We infect, were approved where we have an IRB approval for two different PDL, one inhibitors studies in bladder and kidney cancer with PDL one inhibitor and our modified it respect and just our investigator moved to another hospital. We have to move the approval, but we actually got approved already formal clinical trial because of pilot study data. So yes, modifies it. Respecting is one of the key supplements I give during chemotherapy and during immunotherapy, but it’s a lash supplement at the elevated dose. 

00:39:21
Dr. Isaac Eliaz
Okay. 20 grams a day with your patients who to take before a biopsy or surgery with a high probability of cancer to prevent the spread. It’s essential supplement with radiation therapy, we have published showing how sales, they cannot resist themselves to radiation or not getting killed by radiation therapy. When we add the modifies, it was specked into the same dose of radiation. We get a kill of the sale. We have to publish this paper, all of this because we are changing the microenvironment and we are exposing the cancer cell to the treatment. 

00:40:03
Speaker 2
What about things like, side effects from cancer therapies? for instance, radiation therapy, let’s say breast cancer. You’ve got the radiation dermatitis, you’ve got, CIP in the chemotherapy induced peripheral neuropathy. It’s almost like a necessary poison. The side effect. You need that poison to kill the cancer, but the poison has side effects on healthy tissues can modified citrus, pectin have any effect on, abrogating, these bad effects. 

00:40:35
Dr. Isaac Eliaz
Yes, definitely. Again, your audience are integrative visions. They understand you don’t use only one time, one thing, but yes, especially the radiation side effects because the radiation enhances. If I brought it process in galactic and modifies it to perspective, which is galectin three driven and modifies it, respecting Andrew will cut the process. Definitely, and interestingly enough, for narrow inflammation, which is tricky for narrow inflammation, we have a number of studies showing that when you take a in animal studies, when you induce LPs driven, narrow inflammation, the neuroinflammation is cut significantly and sometimes completely eliminated when you introduce our modifies, it respecting you see a decrease in TNF alpha, and TGF beta in certain interleukins, inflammatory interleukins back to normal level. Yeah. We actually have published papers on this. 

00:41:36
Speaker 2
It seems like that gal three should be measured in all sorts of inflammatory driven diseases. No matter what the etiology, 

00:41:46
Dr. Isaac Eliaz
It’s a, it’s a very good comment. You, and I know it takes now with the internet. It goes faster. It’s not 50 years. It just 20 to 30 years, but galectin three is an approved test in the United States paid by every but every insurance. Again, I mean, I don’t know the situation in Australia, but I can tell you in United States, if you have insurance, the insurance will pay the lab $30 for the collecting sweetest. If you want to pay in cash, they will charge you a 300 to 500. This is the politics of medicine, but there is more and more interest in it. It’s hard to know how to read it. ? Why Because doctors and I really want to encourage anybody who is listening. Doctors love protocol. My, one of my favorite saying is that the only protocol I have is that I don’t have a protocol very important. 

00:42:42
Dr Isaac Eliaz
For patients with congestive heart failure, having galectin three under 17.8, one out of eight will die in one year. ? Okay Why not have a 12.5%? I do a study on 582 people. If you’re collecting threes over 25.6, not such a big difference. 37% will die in one year. If you have a congestive heart failure, you definitely want to check your patient, okay? Because it’s life and death. In the normal population, if you’re collecting to me is 17.5 and the lab Cam’s under 17.8, normal, you are not normal. Everybody’s 10. You have elevated. Galectin three. You have a lot of freeze. You have to read the tests dynamically. It should not determine if you’re going to use modified it respecting or not. I want to emphasize this point is somebody who has done thousands and thousand of Galatians three days. For certain patients like metastatic patients or patients with auto immune diseases, or, fibrotic diseases where there specific galectin with chemistry is demonstrating that as they get worse, they’re connecting as we go up, as they get better, the galectin three goes down for this patient. 

00:44:03
Dr. Isaac Eliaz
Galectin three becomes a great marker. Now you ever do remember, you can have the same amount of galectin suite in the blood, but if it’s blocked by modifying it respecting it’s not, we call it blocked in activated collecting to me. It’s no longer causing damage, right? But over time is inflammation gets reduced. Yoga lectins three gets better. I know I used to volunteer and go up to Tibet to treat the different Buddhist masters. One time, there was really high 14, 15,000 feet. I really, I had knocked it and I was surprised and it probably had somehow damage and it came back. My Galatians three, one 17, they took a modified citrus pectin at the full dose mega lectins. When now is 11. And my arrhythmia went away. Why why it’s 11? Because I’ve less inflammation, but it took a long time of blocking. You don’t want, you want to give, modified it, respecting understanding how fundamental is galectin three. 

00:45:11
Dr. Isaac Eliaz
No some of my colleagues, my friends say, Isaac, how is, how come the word didn’t go out for such a breaks. We know we have over 60 published papers and modified it perspective. We get in average twice a month. Papers for major universities. It’s much bigger than me and my work. Yeah because I was so focused on research and research that I didn’t have time to go around and tell the whole world about it. Now I really feel with what I’m seeing. It’s an essential supplement for every single patient. You can see why you see how many diseases we covered, in the, in this podcast. 

00:45:50
Speaker 2
Okay. Now you’ve mentioned levels of, like 17 is quite high. You mentioned that you got your level down to 11. Now what’s a safe level of gal three. What a normal level. If gal three exists in the body, it exists for a reason what it’s normal functioning. 

00:46:09
Dr. Isaac Eliaz
Oh, of course. Intracellularly it’s functions for normal cell development. For example, American journal of the prodigy is a great article about a year ago, showing galectin three helping nefrogenesis, galectin three target for fighting CKD outside of the cell. Inside the cell, remember we started this conversation by talking about survival. I said, inside the cell survival mean embryogenesis outside. The cell. Survival is a fight because one cell is a part of a community. If it’s a cell wants to survive, doesn’t want to die. It no longer becomes a part of community. It’s really, you can sit in the geopolitical environment, right? This nationalism is creating boundaries. What happens? You create a microenvironment that the body cannot control classically. What happened in cancer. In this sense in galectin three is needed for acute injury repair. What the beauty is that even if you give people, modifies it to respect him, if you need it at a certain place, it will still get expressed where it’s needed. 

00:47:31
Dr Isaac Eliaz
That’s why it’s not a double edged sword, but you got to block it all the time in the circulation. Because Andrew, if you look at numbers, if normal galectin three is 10 and then pretending to the train is the real issue we just doubled. Galectin three. If you look at CRP, you can see a P of under 0.5. When someone is really inflamed, you’ll get 100. It goes up 200 fold. Same with same with cytokines. ? Why Because these are downstream instigators. It’s of change of galectin three turns on the alarm, and then everybody else goes crazy. We are really dealing with the master protein. When do we address it? 

00:48:16
Speaker 2
Modified citrus pectin. Doesn’t infiltrate the cell and disrupts eye embryogenesis and things. 

00:48:23
Dr. Isaac Eliaz
Exactly the other way around. Because when the cell is, remember when the cell receptors are working better and now am PK is working better and mTOR one is shut down. We get 36 molecules of ATP from every glucose we don’t get lucky because he does is when don’t get reactive oxygen species, we’re in great shape. When we go into survival mode, we go to glycolysis. We produce energy 10,000 times faster in efficient. And we change the cell metabolism. We get more hypoxic, it gets worse. That’s why it’s so important to address the galectin three. It’s part of the no interest. People are using Metformin, a compound that they use a lot or Nokia, or is even better benefits. This is intracellularly. Galectin three. Start the process through the cell membrane because cell membrane is really the boundary of the cell. Every cell can look at every cell is I look at it as a living organism with boundaries, with neighbors, with the community. 

00:49:36
Dr Isaac Eliaz
If it’s willing to be a part of a community like being a beehive. I like to say then what K what the big cares is for the beehive to survive. If a big goes crazy and starts attacking me, the other BS behind is not going to work. Collecting three straws of it gets up to the survival. The survival response starts with the sympathetic nervous system in the immediate second response, but then it can quiet down, but the metabolic signal is collecting three, and that’s why it’s so fundamental. It’s such effects, but we don’t have time to talk. You can see in people post them. I who meditate, collecting three, goes down as their heart damage goes down dramatically. Beautiful studies on this human clinical trial, double blind. 

00:50:25
Speaker 2
There is so much more to cover here, but just one last point. You’re talking about stress in the human body. Normally we default to a physical stress or so do emotional stressors increase. Galectin three. What importance do we have to place therefore, on our emotional health? 

00:50:48
Dr. Isaac Eliaz
I can’t thank you enough for making this your last point, because my passion, my third act, I just turned 60 is really teaching meditation and healing because were very unique because they treated these legendary Tibetan must Buddhist masters in Tibet. I was, I was fortunate to get very unique meditation training and I translated it into healing. It’s amazing what emotional psycho-spiritual mental thing can do. The reason is we are built to take stressors and turn them into love and compassion. That’s why I told you the beginning when I told my story, that’s what I meant. And thank you. I don’t know how you do this, but you kind of close the whole thing, because if you think about the heart gives clean blood with no discrimination. They are all water cannot contract or extend like a smaller outdoor y’all. It keeps blood everywhere, open house. 

00:51:46
Dr. Isaac Eliaz
It also feeds itself by the first artery. The author gives blood is the coronary arteries, which means self lab is very important in order for the heart to give clean blood, what does it need? It needs to get dirty blood. It needs to get stuff that the sales feel they don’t want. So we use these stressors. We use dramas in the house, knows how to transform them into clean blood. How does he do it by connecting with the universe, to our breath? We are all a part of one big picture. I go back to survival to sell is part of a tissue. The tissue is part of an organ. The organ is part of a body, and we are part of a community. We are part of the planet and the planet is part of the solar system. It’s all the same. Eventually survival goes all the way to the universe. 

00:52:46
Dr Isaac Eliaz
As long as we see the bigger picture and we let go of our own drama, it’s, we don’t contract into our own drama. We live a healthier, happier life. I sit in my retreats, I see cancer markers. You never logical diseases improving in a few days. Now I’m doing some trials on this in more focused things, but it’s the same thing. It’s the galectin Smith story. I’m writing a book about it that hopefully will be out in a few months. The title is the survival paradox because survival is a paradox. So your question is so, right. We know from the study, I told you about MIS they took patients straight from them. I in 10 patients just didn’t do anything in came patient meditated, just simple meditation, Zen, zip, they improved in perfusion was so dramatic that even on 10, compared to 10 p-value was under 0.001 in collecting three was lower, but when they took them six weeks later and they did another session and they checked galectin three between before the session and after the 20 minute session, okay. 

00:53:56
Dr. Isaac Eliaz
It drew up a 15% in the level of galectin three during the meditation session, after six weeks. So this is the beauty. Now there are so many studies over 9,000 papers and getting three that we have publications and all these insights like that you just said now, it’s nice that there’s research to support, like the insight that you just said. 

00:54:18
Andrew Whitfield
Well, I would love to get you back onto FX medicine at some stage. We can perhaps delve into certain parts of the research that you’ve been involved in. Maybe, also discuss some of the other research that’s moving ahead with galectin three and how to treat it. Dr. Isaac Ally’s I can’t thank you enough. One of the reasons I love FFX medicine is because of meeting people like you, not just an expert, but not just involved in medical science, but is driven by love and compassion. A true doctor. Thank you so much for joining us on ethics medicine today. 

00:54:54
Dr. Isaac Eliaz
Thank you so much. It was truly my honor. I mean, your interview, I must tell you was the most sophisticated interview I’ve ever had, and I’m not saying it lightly, I’ve done hundreds of them. You really know the topic, and I would really be glad if we can have another one. Yeah it was really fun. Thank you to everybody in Australia. 

00:55:13
Andrew Whitfield
This is FX medicine. I’m Andrew Whitfield cook nominations are now open for the bio ceuticals integrative medicine awards. The Beemers recognized professionals who demonstrate excellence in the complementary and integrative medicine profession. Nominate your deserving practitioner. Now by going to bio ceuticals.com and clicking on the education tab.